BackgroundPhysical exercise in cancer patients is a promising intervention to improve cognition and increase brain volume, including hippocampal volume. We investigated whether a 6-month exercise intervention primarily impacts total hippocampal volume and additionally hippocampal subfield volumes, cortical thickness and grey matter volume in previously physically inactive breast cancer patients. Furthermore, we evaluated associations with verbal memory.MethodsChemotherapy-exposed breast cancer patients (stage I-III, 2–4 years post diagnosis) with cognitive problems were included and randomized in an exercise intervention (n = 70, age = 52.5 ± 9.0 years) or control group (n = 72, age = 53.2 ± 8.6 years). The intervention consisted of 2x1 hours/week of supervised aerobic and strength training and 2x1 hours/week Nordic or power walking. At baseline and at 6-month follow-up, volumetric brain measures were derived from 3D T1-weighted 3T magnetic resonance imaging scans, including hippocampal (subfield) volume (FreeSurfer), cortical thickness (CAT12), and grey matter volume (voxel-based morphometry CAT12). Physical fitness was measured with a cardiopulmonary exercise test. Memory functioning was measured with the Hopkins Verbal Learning Test-Revised (HVLT-R total recall) and Wordlist Learning of an online cognitive test battery, the Amsterdam Cognition Scan (ACS Wordlist Learning). An explorative analysis was conducted in highly fatigued patients (score of ≥ 39 on the symptom scale ‘fatigue’ of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire), as previous research in this dataset has shown that the intervention improved cognition only in these patients.ResultsMultiple regression analyses and voxel-based morphometry revealed no significant intervention effects on brain volume, although at baseline increased physical fitness was significantly related to larger brain volume (e.g., total hippocampal volume: R = 0.32, B = 21.7 mm3, 95 % CI = 3.0 – 40.4). Subgroup analyses showed an intervention effect in highly fatigued patients. Unexpectedly, these patients had significant reductions in hippocampal volume, compared to the control group (e.g., total hippocampal volume: B = −52.3 mm3, 95 % CI = −100.3 – −4.4)), which was related to improved memory functioning (HVLT-R total recall: B = −0.022, 95 % CI = −0.039 – −0.005; ACS Wordlist Learning: B = −0.039, 95 % CI = −0.062 – −0.015).ConclusionsNo exercise intervention effects were found on hippocampal volume, hippocampal subfield volumes, cortical thickness or grey matter volume for the entire intervention group. Contrary to what we expected, in highly fatigued patients a reduction in hippocampal volume was found after the intervention, which was related to improved memory functioning. These results suggest that physical fitness may benefit cognition in specific groups and stress the importance of further research into the biological basis of this finding.
MULTIFILE
There are three volumes in this body of work. In volume one, we lay the foundation for a general theory of organizing. We propose that organizing is a continuous process of ongoing mutual or reciprocal influence between objects (e.g., human actors) in a field, whereby a field is infinite and connects all the objects in it much like electromagnetic fields influence atomic and molecular charged objects or gravity fields influence inanimate objects with mass such as planets and stars. We use field theory to build what we now call the Network Field Model. In this model, human actors are modeled as pointlike objects in the field. Influence between and investments in these point-like human objects are explained as energy exchanges (potential and kinetic) which can be described in terms of three different types of capital: financial (assets), human capital (the individual) and social (two or more humans in a network). This model is predicated on a field theoretical understanding about the world we live in. We use historical and contemporaneous examples of human activity and describe them in terms of the model. In volume two, we demonstrate how to apply the model. In volume 3, we use experimental data to prove the reliability of the model. These three volumes will persistently challenge the reader’s understanding of time, position and what it means to be part of an infinite field. http://dx.doi.org/10.5772/intechopen.99709
Like a marker pen on a map, the Covid-19 pandemic drastically highlighted the persisting existence of borders that used to play an ever decreasing role in people´s perception and behavior over the last decades. Yes, inner European borders are open in normal times. Yes, people, goods, services and ideas are crossing the border between Germany and the Netherlands freely. Yet we see that the border can turn into a barrier again quickly and effectively and it does so in many dimensions, some of them being not easily visible. Barriers hinder growth, development and exchange and in spite of our progress in creating a borderless Europe, borders still create barriers in many domains. Differing labor law, social security and tax systems, heterogeneous education models, small and big cultural differences, language barriers and more can impose severe limitations on people and businesses as they cross the border to travel, shop, work, hire, produce, buy, sell, study and research. Borders are of all times and will therefore always exist. But as they did so for a long time, huge opportunities can be found in overcoming the barriers they create. The border must not necessarily be a dividing line between two systems. It has the potential to become a center of growth and progress that build on joint efforts, cross-border cooperation, mutual learning and healthy competition. Developing this inherent potential of border regions asks for politics, businesses and research & education on both sides of the border to work together. The research group Cross-Border Business Development at Fontys University of Applied Science in Venlo conducts applied research on the impact of the national border on people and businesses in the Dutch-German border area. Students, employees, border commuters, entrepreneurs and employers all face opportunities as well as challenges due to the border. In collaboration with these stakeholders, the research chair aims to create knowledge and provide solutions towards a Dutch-German labor market, an innovative Dutch-German borderland and a futureproof Cross-Border economic ecosystem. This collection is not about the borderland in times of COVID-19. Giving meaning to the borderland is an ongoing process that started long before the pandemic and will continue far beyond. The links that have been established across the border and those that will in the future are multifaceted and so are the topics in this collection. Vincent Pijnenburg outlines a broader and introductory perspective on the dynamics in the Dutch-German borderland.. Carla Arts observes shopping behavior of cross-border consumers in the Euregion Rhine-Meuse-North. Jan Lucas explores the interdependencies of the Dutch and German economies. Jean Louis Steevensz presents a cross-border co-creation servitization project between a Dutch supplier and a German customer. Vincent Pijnenburg and Patrick Szillat analyze the exitence of clusters in the Dutch-German borderland. Christina Masch and Janina Ulrich provide research on students job search preferences with a focus on the cross-border labor market. Sonja Floto-Stammen and Natalia Naranjo-Guevara contribute a study of the market for insect-based food in Germany and the Netherlands. Niklas Meisel investigates the differences in the German and Dutch response to the Covid-19 crisis. Finally, Tolga Yildiz and Patrick Szillat show differences in product-orientation and customer-orientation between Dutch and German small and medium sized companies. This collection shows how rich and different the links across the border are and how manifold the perspectives and fields for a cross-border approach to regional development can be. This publication is as well an invitation. Grasping the opportunities that the border location entails requires cooperation across professional fields and scientific disciplines, between politics, business and researchers. It needs the contact with and the contribution of the people in the region. So do what we strive for with our cross-border research agenda: connect!
The objective of CW4N is to identify opportunities for wood reuse through the use of advanced digital production technologies1, and develop related implementation strategies for public organisations, in particular housing corporations and municipalities. Strategies include concrete proposals on how to: a) collect and process wood waste from residential buildings; b) add value to reclaimed wood by means of digital production; c) increase tenant involvement and acceptance for waste wood collection and circular reuse; d) create impactful applications for a circular economy. The research is carried out in four work packages. The first identifies the nature of residential wood waste (volume, type, application) from past case projects of housing corporations Ymere and Rochdale. Their upcoming renovation plans are evaluated, to identify resources and hotspots for future implementations. The second workpackage explores what applications can be conceived, given the available wood and digital production tools at the AUAS Robot Lab. In the third workpackage case studies are carried out for actual projects of the housing corporations. Physical prototypes are used as conversation pieces to involve tenants and increase their acceptance for circular applications. In the fourth workpackage all findings are combined in a set of implementation strategies. High-quality data-collection is crucial for the project, since it will determine the nature of the materials for designing and manufacturing applications. In this proposal, additional resources are added to the project to take care of data-collection. Due to covid-19, project managers at Ymere and Rochdale must focus on day-to-day work to get ongoing and planned building projects done, reducing their time for data collection from previous projects. In addition, because of teleworking, non-digital data such as drawings and reports are not easily accessible. To enhance data-collection, student-assistants will be added to the project to survey ongoing renovation projects in the field.
