The specificity of training for races is believed to be important for performance development. However, measuring specificity is challenging. This study aimed to develop a method to quantify the specificity of speed skating training for sprint races (i.e., 500 and 1,000 m), and explore the amount of training specificity with a pilot study. On-ice training and races of 10 subelite-to-elite speed skaters were analyzed during 1 season (i.e., 26 weeks). Intensity was mapped using 5 equal zones, between 4 m·s-1 to peak velocity and 50% to peak heart rate. Training specificity was defined as skating in the intensity zone most representative for the race for a similar period as during the race. During the season, eight 500 m races, seven 1,000 m races, and 509 training sessions were analyzed, of which 414 contained heart rate and 375 sessions contained velocity measures. Within-subject analyses were performed. During races, most time was spent in the highest intensity zone (Vz5 and HRz5). In training, the highest velocity zone Vz5 was reached 107 ± 28 times, with 9 ± 3 efforts (0.3 ± 0.1% training) long enough to be considered 500 m specific, 6 ± 5 efforts (0.3 ± 0.3% training) were considered 1,000 m specific. For heart rate, HRz5 was reached 151 ± 89 times in training, 43 ± 33 efforts (1.3 ± 0.9% training) were considered 500 m specific, and 36 ± 23 efforts (3.2 ± 1.7% training) were considered 1,000 m specific. This newly developed method enables the examination of training specificity so that coaches can control whether their intended specificity was reached. It also opens doors to further explore the impact of training specificity on performance development.
The study used a research-through-design approach and organized game jams as a method to examine game design processes, with the aim to investigate how the diverse identities of designers affect and inspire their game designs. During the Game [4Diversity] Jams we hypothesised that homogeneity in groups may lead to a single-minded message in their games, and diversity in groups may result in games that allow more freedom for players to create their own personal interpretation(s) of the game's content and mechanics. The results of this study suggest that a narrow theme and diverse team composition may assist designers in creating novel games. As such, designers can find diverse gameplay and content from additional specificity in the game jam's organisation.
Standard SARS-CoV-2 testing protocols using nasopharyngeal/throat (NP/T) swabs are invasive and require trained medical staff for reliable sampling. In addition, it has been shown that PCR is more sensitive as compared to antigen-based tests. Here we describe the analytical and clinical evaluation of our in-house RNA extraction-free saliva-based molecular assay for the detection of SARS-CoV-2. Analytical sensitivity of the test was equal to the sensitivity obtained in other Dutch diagnostic laboratories that process NP/T swabs. In this study, 955 individuals participated and provided NP/T swabs for routine molecular analysis (with RNA extraction) and saliva for comparison. Our RT-qPCR resulted in a sensitivity of 82,86% and a specificity of 98,94% compared to the gold standard. A false-negative ratio of 1,9% was found. The SARS-CoV-2 detection workflow described here enables easy, economical, and reliable saliva processing, useful for repeated testing of individuals.
LINK
Vanuit het bedrijfsleven is vraag naar het ontwikkelen van coatings met specifieke hoogwaardige eigenschappen. Een technisch haalbare en kosten efficiënte methode om dit te doen is door het inmengen van nanodeeltjes in coatings of in polymeren. Op dit moment is de beschikbaarheid (op grotere schaal) van hoogwaardige nanodeeltjes (grootte en deeltjesgrootte distributie) echter nog een knelpunt. Microreactortechnologie kan hiervoor een goede uitkomst bieden. In een microreactor kunnen reactiecondities zeer goed gecontroleerd worden en daardoor zal de reproduceerbaarheid goed zijn. Ook is het eenvoudig om een reactie in een microreactor op te schalen naar een groter volume. In het RAAK-MKB project Flow4Nano worden 2 sleutel technologieën van het lectoraat Material Sciences van Zuyd Hogeschool bij elkaar gebracht: nanotechnologie en microreactor technologie. In dit project zal de focus liggen op de toepassing van nanodeeltjes in optische coating voor zonnecellen en voor glastuinbouw. De toepassing in zonnecellen is een focus van het lectoraat Zonne Energie in de Gebouwde Omgeving van Zuyd. De toepassing in de glastuinbouw is een focus van de Hogeschool Arnhem Nijmegen in het lectoraat duurzame energie. De onderzoekvraag voor dit project is: “Can we produce nanoparticles with high specificity for use in advanced coatings and polymers with tailored functionalities for application in greenhouses and solar cells using (micro)flow?” De consortiumleden Zuyd Hogeschool / lectoraat material sciences (microreactor technologie / nanotechnologie), TNO/brightlands Material Centre (nanomaterialen voor energietoepassingen), Kriya Materials (producent nanodeeltjes) en Chemtrix (microflow apparatuur) zullen TiO2 en ZnO nanodeeltjes maken en karakteriseren. De consortiumpartners Zuyd / lectoraat Zonne-energie in de duurzaam gebouwde omgevingen HAN (lectoraat duurzame energie) zullen de geproduceerde nanodeeltjes testen in optisch actieve coatings voor toepassingen in zonne-energie en glastuinbouw respectievelijk. De consortiumpartner NanoHouse zal het stuk disseminatie op zich nemen.
Fluorescence microscopy is an indispensable technique to resolve structure and specificity in many scientific areas such as diagnostics, health care, materials- and life sciences. With the development of multi-functional instruments now costing hundreds of thousands of Euros, the availability and access to high-tech instrumentation is increasingly limited to larger imaging facilities. Here, we will develop a cost-effective alternative by combining a commercially available solution for high-resolution confocal imaging (the RCM from confocal.nl) with an open-hardware microscopy framework, the miCube, developed in the Laboratory of Biophysics of Wageningen University & Research. In addition, by implementing a recent invention of the applicant for the spectral separation of different emitters, we will improve the multiplexing capabilities of fluorescence microscopy in general and the RCM in particular. Together, our new platform will help to translate expertise and know-how created in an academic environment into a commercially sustainable future supporting the Dutch technology landscape.
Wildlife crime is an important driver of biodiversity loss and disrupts the social and economic activities of local communities. During the last decade, poaching of charismatic megafauna, such as elephant and rhino, has increased strongly, driving these species to the brink of extinction. Early detection of poachers will strengthen the necessary law enforcement of park rangers in their battle against poaching. Internationally, innovative, high tech solutions are sought after to prevent poaching, such as wireless sensor networks where animals function as sensors. Movement of individuals of widely abundant, non-threatened wildlife species, for example, can be remotely monitored ‘real time’ using GPS-sensors. Deviations in movement of these species can be used to indicate the presence of poachers and prevent poaching. However, the discriminative power of the present movement sensor networks is limited. Recent advancements in biosensors led to the development of instruments that can remotely measure animal behaviour and physiology. These biosensors contribute to the sensitivity and specificity of such early warning system. Moreover, miniaturization and low cost production of sensors have increased the possibilities to measure multiple animals in a herd at the same time. Incorporating data about within-herd spatial position, group size and group composition will improve the successful detection of poachers. Our objective is to develop a wireless network of multiple sensors for sensing alarm responses of ungulate herds to prevent poaching of rhinos and elephants.
