Inhibition of the sodium−glucose cotransporter 2 (SGLT2) by canagliflozin in type 2 diabetes mellitus results in large between-patient variability in clinical response. To better understand this variability, the positron emission tomography (PET) tracer [18F]canagliflozin was developed via a Cu-mediated 18F-fluorination of its boronic ester precursor with a radiochemical yield of 2.0 ± 1.9% and a purity of >95%. The GMP automated synthesis originated [18F]canagliflozin with a yield of 0.5−3% (n = 4) and a purity of >95%. Autoradiography showed [18F]canagliflozin binding in human kidney sections containing SGLT2. Since [18F]canagliflozin is the isotopologue of the extensively characterized drug canagliflozin and thus shares its toxicological and pharmacological characteristics, it enables its immediate use in patients.
Inhibition of the sodium−glucose cotransporter 2 (SGLT2) by canagliflozin in type 2 diabetes mellitus results in large between-patient variability in clinical response. To better understand this variability, the positron emission tomography (PET) tracer [18F]canagliflozin was developed via a Cu-mediated 18F-fluorination of its boronic ester precursor with a radiochemical yield of 2.0 ± 1.9% and a purity of >95%. The GMP automated synthesis originated [18F]canagliflozin with a yield of 0.5−3% (n = 4) and a purity of >95%. Autoradiography showed [18F]canagliflozin binding in human kidney sections containing SGLT2. Since [18F]canagliflozin is the isotopologue of the extensively characterized drug canagliflozin and thus shares its toxicological and pharmacological characteristics, it enables its immediate use in patients.
The SynergyS project aims to develop and assess a smart control system for multi-commodity energy systems (SMCES). The consortium, including a broad range of partners from different sectors, believes a SMCES is better able to incorporate new energy sources in the energy system. The partners are Hanze, TU Delft, University of Groningen, TNO, D4, Groningen Seaports, Emerson, Gain Automation Technology, Energy21, and Enshore. The project is supported by a Energy Innovation NL (topsector energie) subsidy by the Ministry of Economic Affairs.Groningen Seaports (Eemshaven, Chemical Park Delfzijl) and Leeuwarden are used as case studies for respectively an industrial and residential cluster. Using a market-based approach new local energy markets have been developed complementing the existing national wholesale markets. Agents exchange energy using optimized bidding strategies, resulting in better utilization of the assets in their portfolio. Using a combination of digital twins and physical assets from two field labs (ENTRANCE, The Green Village) performance of the SMCES is assessed. In this talk the smart multi-commodity energy system is presented, as well as some first results of the assessment. Finally an outlook is given how the market-based approach can benefit the development of energy hubs.
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