Psoriasis (Pso) is a chronic inflammatory skin disease, and up to 30% of Pso patients develop psoriatic arthritis (PsA), which can lead to irreversible joint damage. Early detection of PsA in Pso patients is crucial for timely treatment but difficult for dermatologists to implement. We, therefore, aimed to find disease-specific immune profiles, discriminating Pso from PsA patients, possibly facilitating the correct identification of Pso patients in need of referral to a rheumatology clinic. The phenotypes of peripheral blood immune cells of consecutive Pso and PsA patients were analyzed, and disease-specific immune profiles were identified via a machine learning approach. This approach resulted in a random forest classification model capable of distinguishing PsA from Pso (mean AUC = 0.95). Key PsA-classifying cell subsets selected included increased proportions ofdifferentiated CD4+CD196+CD183-CD194+ and CD4+CD196-CD183-CD194+ T-cells and reduced proportions of CD196+ and CD197+ monocytes, memory CD4+ and CD8+ T-cell subsets and CD4+ regulatory T-cells. Within PsA, joint scores showed an association with memory CD8+CD45RACD197- effector T-cells and CD197+ monocytes. To conclude, through the integration of in-depth flow cytometry and machine learning, we identified an immune cell profile discriminating PsA from Pso. This immune profile may aid in timely diagnosing PsA in Pso.
MULTIFILE
Hand function in children is very important in the development of skills needed for daily childhood activities; therefore, preserving this function warrants special attention. One of the interventions aiming to preserve functionis splinting of the affected wrist joint. The rationale for the use of splinting is to balance rest and activity, therebypreserving wrist function. However, the evidence-based knowledge to support this rationale is scarce. To determine the validity of “balancing rest and activity of the affected wrists to preserve function,” we reviewed ourown data, data in the literature regarding rheumatic wrist problems in children, and data from a 15-year followup study of rheumatic wrist problems in an adult cohort of our adult rheumatology counterpart within the medicalcenter.
In Amsterdam kampt een derde van de mensen met meerdere aandoeningen waaronder chronische gewrichtsaandoeningen. Mensen met chronische gewrichtsaandoeningen hebben vaak beperkingen in hun dagelijks functioneren. Leefstijlfactoren zoals overgewicht en inactiviteit spelen een belangrijke rol in het ontstaan van beperkingen in het dagelijks functioneren. Lector chronische gewrichtsaandoeningen dr. Martin van der Esch gaat in zijn rede in op de relatie tussen gewrichtsaandoeningen en beperkingen in dagelijks functionerenen de mogelijkheden om beperkingen te voorkomen of te verminderen. Hij zal hiaten in kennis toelichten en ingaanop de integratie van onderzoek in het onderwijs. Het bijzonder lectoraat chronische gewrichtsaandoeningen isingesteld in samenwerking met Reade, centrum voor revalidatie en reumatologie te Amsterdam
