Skeletal muscle uncoupling protein-3 restores upon intervention in the pre-diabetic and diabetic state: implications for diabetes pathogenesis?

Both exercise training and a lifestyle-intervention program increase UCP3 protein content inskeletal muscle of subjects with reduced glycaemic control, indicating a restoration towards normal UCP3 levels. These data support the idea that UCP3 has a role in the aetiology of type 2 diabetes mellitus