Airline ground operations are subject to the conflicting demands of short turn-around times and safety requirements. They involve multiple parties, but are less regulated than airborne processes. Not surprisingly, more than a quarter of all aircraft incidents occur on the ground. These incidents lead to aircraft damage and associated costs, risk of injuries, and can potentially impact in-flight safety. KLM Ground Services has targeted platform safety performance as an area for improvement. However, existing safety awareness programs have had limited effect. A direct link between safety culture surveys and safety performance has not been established, and therefore these are insufficient to give adequate feedback on interventions. Newly developed by the Texas University are the Line Operations Safety Assessments (LOSA), first targeted at cockpit operations. Variants are available since October 2010 for the platform and maintenance environments. The research group for Aviation Engineering at the Amsterdam University of Applied Sciences has used the original platform LOSA material and tailored these to the specific circumstances at KLM. Results to date show that with these modifications, platform LOSA is a useful tool to quantify safety performance and to generate trend data. The effect of safety interventions can now be monitored. Referentie de Boer, R.J., Koncak, B., Habekotté, R., & van Hilten, G.J. (2011), Introduction of ramp-LOSA at KLM Ground Services , Human Factors and Ergonomics Society Annual Meeting, Leeds, United Kingdom
OBJECTIVE: To further test the validity and clinical usefulness of the steep ramp test (SRT) in estimating exercise tolerance in cancer survivors by external validation and extension of previously published prediction models for peak oxygen consumption (Vo2peak) and peak power output (Wpeak).DESIGN: Cross-sectional study.SETTING: Multicenter.PARTICIPANTS: Cancer survivors (N=283) in 2 randomized controlled exercise trials.INTERVENTIONS: Not applicable.MAIN OUTCOME MEASURES: Prediction model accuracy was assessed by intraclass correlation coefficients (ICCs) and limits of agreement (LOA). Multiple linear regression was used for model extension. Clinical performance was judged by the percentage of accurate endurance exercise prescriptions.RESULTS: ICCs of SRT-predicted Vo2peak and Wpeak with these values as obtained by the cardiopulmonary exercise test were .61 and .73, respectively, using the previously published prediction models. 95% LOA were ±705mL/min with a bias of 190mL/min for Vo2peak and ±59W with a bias of 5W for Wpeak. Modest improvements were obtained by adding body weight and sex to the regression equation for the prediction of Vo2peak (ICC, .73; 95% LOA, ±608mL/min) and by adding age, height, and sex for the prediction of Wpeak (ICC, .81; 95% LOA, ±48W). Accuracy of endurance exercise prescription improved from 57% accurate prescriptions to 68% accurate prescriptions with the new prediction model for Wpeak.CONCLUSIONS: Predictions of Vo2peak and Wpeak based on the SRT are adequate at the group level, but insufficiently accurate in individual patients. The multivariable prediction model for Wpeak can be used cautiously (eg, supplemented with a Borg score) to aid endurance exercise prescription.
To treat microbial infections, antibiotics are life-saving but the increasing antimicrobial resistance is a World-wide problem. Therefore, there is a great need for novel antimicrobial substances. Fruit and flower anthocyanins have been recognized as promising alternatives to traditional antibiotics. How-ever, for future application as innovative alternative antibiotics, the full potential of anthocyanins should be further investigated. The antimicrobial potential of anthocyanin mixtures against different bacterial species has been demonstrated in literature. Preliminary experiments performed by our laboratories, using grape, rose and red cabbage anthocyanins against S. aureus and E. coli confirmed the antimicrobial potential of these substances. Hundreds of different anthocyanin entities have been described. However, which of these entities hold antimicrobial effects is currently unknown. Our preliminary data show that an-thocyanins extracted from grape, rose and red cabbage contain different collections of anthocyanin entities with differential antimicrobial efficacies. Our focus is on the extraction and characterization of anthocyanins from various crop residues. Grape peels are residues in the production of wine, while red rose and tulip leaves are residues in the production of tulip bulbs and regular horticulture. The presence of high-grade substances for pharmacological purposes in these crops may provide an innovative strategy to add value to other-wise invaluable crop residues. This project will be performed by the collaborative effort of our institute together with the Medi-cal Microbiology department of the University Medical Center Groningen (UMCG), 'Wijnstaete', a small-scale wine-producer (Lemelerveld) and Imenz Bioengineering (Groningen), a company that develops processes to improve the production of biobased chemicals from waste products. Within this project, we will focus on the antimicrobial efficacy of anthocyanin-mixtures from sources that are abundantly and locally available as a residual waste product. The project is part of a larger re-search effect to further characterize, modify and study the antimicrobial effects of specific anthocy-anin entities.
Ten gevolge van de klimaatverandering Nederland bedreigt. De Verenigde Naties benoemt ‘17 Gobal Goals for a Sustainable Development’ nader gespecificeerd. Goal 13:” versterk de veerkracht en het aanpassingsvermogen aan klimaatgerelateerde gevaren en natuurrampen”. Deze klimaatverandering vraagt om een continue inzicht in de waterafvoercapaciteit van Nederlandse water-infrastructuur. Autonome vaartuigen maken een continue bemeting en realtime informatie van de vaarwegen mogelijk op basis waarvan waar snel actie ondernomen kan worden. Diverse partijen zowel publiek als privaat hebben de wens om continue en autonoom te varen en zijn afzonderlijk hiermee bezig zoals onder andere Rijkswaterstaat, Saeport Groningen en Provincie Overijssel . Het lectoraat mechatronica, dat succesvol onderzoek doet naar ‘autonome systemen in ongestructureerde omgevingen’ heeft veel kennis en ervaring op het gebied van grond (2D navigatie) en lucht robots (3D navigatie). Deze ontwikkelde technologieën zijn potentieel zeer geschikt voor navigatie op het water (2D, 2.5D) en onderwater (3D). Tijdens de vraaginventarisatie bleek er reeds veel interesse van partijen om kennis te delen en samen door te ontwikkelen. Er zijn semi-autonome vaartuigen beschikbaar hiervoor, maar bij de partijen ontbrak een totaal overzicht van de huidige stand van der technologie. Daarom wil het lectoraat Mechatronica samen met Marinminds, Aquatic Drones en DronExpert een onderzoek uitvoeren naar de ‘State of the Art’ betreft autonoom varen. In dit project zal dit onderzoek worden uitgevoerd door specificatie van de gewenste functionele bouwblokken (WP1), een state-of-the art van beschikbare technische oplossingen (WP2), een Gap-analysis tussen deze beide (WP3), verkennende experimenten hiernaar met behulp van een demonstrator (WP4) en een nieuwe specifiek gemaakte projectaanvraag (WP5). Dit cross-over project van de topsector HTSM/SmartIndustry met de topsector Water & Maritiem versterkt al direct de kennispositie van alle betrokken partijen, waardoor deze consortia sneller de vaarwegen klimaat-adaptief kunnen maken, zodat daarmee de Nederlandse (water) veiligheid beter wordt geborgd.
