A presentation about a skills gap: industry demands versus learning outcomes. The presentation deals with ongoing research about workplace learning in computing curricula.
In the coming decades, a substantial number of electric vehicle (EV) chargers need to be installed. The Dutch Climate Accord, accordingly, urges for preparation of regional-scale spatial programs with focus on transport infrastructure for three major metropolitan regions among them Amsterdam Metropolitan Area (AMA). Spatial allocation of EV chargers could be approached at two different spatial scales. At the metropolitan scale, given the inter-regional flow of cars, the EV chargers of one neighbourhood could serve visitors from other neighbourhoods during days. At the neighbourhood scale, EV chargers need to be allocated as close as possible to electricity substations, and within a walkable distance from the final destination of EV drivers during days and nights, i.e. amenities, jobs, and dwellings. This study aims to bridge the gap in the previous studies, that is dealing with only of the two scales, by conducting a two-phase study on EV infrastructure. At the first phase of the study, the necessary number of new EV chargers in 353 4-digit postcodes of AMA will be calculated. On the basis of the findings of the Phase 1, as a case study, EV chargers will be allocated at the candidate street parking locations in the Amsterdam West borough. The methods of the study are Mixed-integer nonlinear programming, accessibility and street pattern analysis. The study will be conducted on the basis of data of regional scale travel behaviour survey and the location of dwellings, existing chargers, jobs, amenities, and electricity substations.
CRISPR/Cas genome engineering unleashed a scientific revolution, but entails socio-ethical dilemmas as genetic changes might affect evolution and objections exist against genetically modified organisms. CRISPR-mediated epigenetic editing offers an alternative to reprogram gene functioning long-term, without changing the genetic sequence. Although preclinical studies indicate effective gene expression modulation, long-term effects are unpredictable. This limited understanding of epigenetics and transcription dynamics hampers straightforward applications and prevents full exploitation of epigenetic editing in biotechnological and health/medical applications.Epi-Guide-Edit will analyse existing and newly-generated screening data to predict long-term responsiveness to epigenetic editing (cancer cells, plant protoplasts). Robust rules to achieve long-term epigenetic reprogramming will be distilled based on i) responsiveness to various epigenetic effector domains targeting selected genes, ii) (epi)genetic/chromatin composition before/after editing, and iii) transcription dynamics. Sustained reprogramming will be examined in complex systems (2/3D fibroblast/immune/cancer co-cultures; tomato plants), providing insights for improving tumor/immune responses, skin care or crop breeding. The iterative optimisations of Epi-Guide-Edit rules to non-genetically reprogram eventually any gene of interest will enable exploitation of gene regulation in diverse biological models addressing major societal challenges.The optimally balanced consortium of (applied) universities, ethical and industrial experts facilitates timely socioeconomic impact. Specifically, the developed knowledge/tools will be shared with a wide-spectrum of students/teachers ensuring training of next-generation professionals. Epi-Guide-Edit will thus result in widely applicable effective epigenetic editing tools, whilst training next-generation scientists, and guiding public acceptance.
A number of universities of applied sciences do a lot of research in the field of sustainable last mile logistics. Collaboration and coordination take place through joint projects or through seminars. However, this collaboration could be more structured so that researchers can always take full advantage of each other's knowledge and are not dependent on having or not having joint projects or seminars. This also concerns the question of how these studies can gain extra added value through joint programming (this can partly be done in the development of a tool/benchmark, see previous point), but also in having and getting research and knowledge from the different regions. Within the new research agenda of the Logistics Knowledge Agreement (the lectors platform of the CoE KennisDC Logistics), urban logistics has been named as one of the four core themes on which the involved universities of applied sciences want to collaborate across regions. In addition, there is only limited cooperation in the field of education around the theme of “urban logistics”. Students who want to graduate in urban logistics or do internships must therefore first learn a lot.
