Background: Weight loss is key to treatment of older adults with obesity and type 2 diabetes, but also a risk for muscle mass loss. This study investigated whether a whey protein drink enriched with leucine and vitamin D could preserve muscle mass and improve glycemic control during combined lifestyle intervention in this population. Methods: 123 older adults with obesity and type 2 diabetes were randomized into a 13-week lifestyle intervention with dietary advice and exercise, receiving either the enriched protein drink (test) or an isocaloric control (control). Muscle mass was assessed with dual-energy X-ray absorptiometry and glycemic control by oral glucose tolerance test. Statistical analyses were performed using a linear mixed model. Results: There was a nonsignificant increase in leg muscle mass (+0.28 kg; 95% CI, −0.01 to 0.56) and a significant increase in appendicular muscle mass (+0.36 kg; 95% CI, 0.005 to 0.71) and total lean mass (+0.92 kg; 95% CI, 0.19 to 1.65) in test vs. control. Insulin sensitivity (Matsuda index) also increased in test vs. control (+0.52; 95% CI, 0.07 to 0.97). Conclusions: Use of an enriched protein drink during combined lifestyle intervention shows beneficial effects on muscle mass and glycemic control in older adults with obesity and type 2 diabetes.
Background: Weight loss is key to treatment of older adults with obesity and type 2 diabetes, but also a risk for muscle mass loss. This study investigated whether a whey protein drink enriched with leucine and vitamin D could preserve muscle mass and improve glycemic control during combined lifestyle intervention in this population. Methods: 123 older adults with obesity and type 2 diabetes were randomized into a 13-week lifestyle intervention with dietary advice and exercise, receiving either the enriched protein drink (test) or an isocaloric control (control). Muscle mass was assessed with dual-energy X-ray absorptiometry and glycemic control by oral glucose tolerance test. Statistical analyses were performed using a linear mixed model. Results: There was a nonsignificant increase in leg muscle mass (+0.28 kg; 95% CI, −0.01 to 0.56) and a significant increase in appendicular muscle mass (+0.36 kg; 95% CI, 0.005 to 0.71) and total lean mass (+0.92 kg; 95% CI, 0.19 to 1.65) in test vs. control. Insulin sensitivity (Matsuda index) also increased in test vs. control (+0.52; 95% CI, 0.07 to 0.97). Conclusions: Use of an enriched protein drink during combined lifestyle intervention shows beneficial effects on muscle mass and glycemic control in older adults with obesity and type 2 diabetes.
PURPOSE OF REVIEW: The loss of muscle mass in critically ill patients contributes to morbidity and mortality, and results in impaired recovery of physical functioning. The number of publications on the topic is increasing. However, there is a lack of consistent methodology and the most optimal methodology remains unclear, hampering its broad use in clinical practice.RECENT FINDINGS: There is a large variety of studies recently published on the use of ultrasound for assessment of muscle mass. A selection of studies has been made, focusing on monitoring of muscle mass (repeated measurements), practical aspects, feasibility and possible nutrition and physical therapy interventions. In this review, 14 new small (n = 19-121) studies are categorized and reviewed as individual studies.SUMMARY: The use of ultrasound in clinical practice is feasible for monitoring muscle mass in critically ill patients. Assessment of muscle mass by ultrasound is clinically relevant and adds value for guiding therapeutic interventions, such as nutritional and physical therapy interventions to maintain muscle mass and promote recovery in critically ill patients.
Relatie tussen spiermassa en vroegtijdig stoppen van chemotherapie bij patienten met hoofd-halskankerIn this study, we aim to assess whether low pre-treatment muscle mass, measured with CT at thoracic (T4) or lumbar level (L3) is associated with early termination of chemotherapy related to toxicity in head and neck cancer (HNC) patients.
Het aantal migrantenouderen neemt sterk toe. Zij hebben een slechtere gezondheid dan autochtone ouderen. Zo komen chronische ziekten zoals obesitas en diabetes type 2 vaker voor. Een van de belangrijkste onderliggende oorzaken van deze ziekten is sarcopenie, verlies van spiermassa en fysiek functioneren van ouderen. Te weinig bewegen en een inadequate eiwitinname spelen een essentiële rol bij sarcopenie en daarbij ook bij chronische ziekten. Inzicht in sarcopenie, het beweegpatroon en de eiwitinname van migrantenouderen zijn onvoldoende beschikbaar. MKB-praktijken voor fysiotherapie en diëtetiek zien businesskansen om specifiek voor deze sterk groeiende doelgroep expertise op te bouwen en daarmee een groot aantal klanten te kunnen bedienen en te behouden. Het ontbreekt de praktijken echter aan de nieuwste kennis en inzichten voor een effectieve behandeling van sarcopenie bij migrantenouderen. Er zijn geen behandelprogramma’s beschikbaar die zij kunnen gebruiken. Daarnaast ondervinden zij met deze doelgroep problemen met de taal, opleidingsniveau en cultuurverschillen. Voor deze vraag van de MKB-praktijken wordt een beweeg- en voeding programma ontwikkeld speciaal gericht op de behoeften van migrantenouderen, fysiotherapeuten en diëtisten. Middels focusgroepen worden de behoeften van professionals en migrantenouderen onderzocht en voorspellers van beweeg- en voedinggedrag in kaart gebracht. Tevens wordt het fysiek functioneren, lichaams-samenstelling, beweeg- en voedingspatroon van verschillende migrantenouderen populaties geanalyseerd. Gebaseerd op deze uitkomsten wordt een nieuw beweeg en voedingsprogramma ontwikkeld om spiermassa en het fysiek functioneren van migrantenouderen te verbeteren (ProMIO programma). Hiervoor kunnen we gebruik maken van het ProMuscle programma, een succesvol voedings- en beweegprogramma voor sarcopenie uitkomsten voor ouderen. Middels een pilot studie wordt het ProMIO programma in de praktijk geëvalueerd op proces, haalbaarheid en bruikbaarheid voor de professional en migrantenouderen en wordt de effectiviteit op sarcopenie uitkomsten getoetst. De resultaten zullen worden gecommuniceerd naar de beroepenvelden en worden ingebed in het HBO-onderwijs.
The admission of patients to intensive care units (ICU) is sometimes planned after a large operation. However, most admissions are acute, because of life-threatening infections or trauma as a result of accidents. Their stay can last from a couple of days to a couple of weeks. ICU patients are often in pain, in fragile health condition, and connected to various devices such as a ventilator, intravenous drip, and monitoring equipment. The resulting lack of mobilization, makes patients lose 1-3% of muscle power for each day they are in the ICU. Within 2 weeks, patients can lose up to 50% of their muscle mass. Early mobilization of ICU patients reduces their time on a respirator and their hospital length of stay. Because of this, ICUs have started early mobilization physical therapy. However, there is a lack of solutions for patients that properly handle fear of movement, are sufficiently personalized to the possibilities and needs of the individual and motivate recurring use in this context. Meanwhile, various technological advances enable new solutions that might bring benefits for this specific use case. Hospitals are experimenting with screens and projections on walls and ceilings to improve their patients’ stay. Standalone virtual reality and mixed reality headsets have become affordable, available and easy to use. In this project, we want to investigate: How can XR-technologies help long-stay ICU patients with early mobilization, with specific attention to the issues of fear of movement, personalization to the individual’s possibilities, needs and compliance over multiple sessions? The research will be carried out in co-creation with the target group and will consist of a state-of-the-art literature review and an explorative study.
