A substantial proportion of patients with burn injury develop chronic itch, which can severely affect their quality of life. As found in research on chronic pain, different psychophysiological processes may also play a role in chronic itch, of which central sensitization, conditioned modulation, and attentional processes have been studied most frequently. This study aimed to explore psychophysiological processes of chronic post-burn itch by comparing 15 patients with long-term itch due to burn injury with 15 matched healthy controls. Exploratory results indicated tendencies for higher itch sensitivity in patients than in controls, for mechanical stimuli and histamine, but not for electrical stimulation. Results further suggest that the efficacy of itch modulation by an itch- or pain-conditioning stimulus or directing attention towards itch stimuli do not differ between these patients and controls. Further elucidation of the processes underlying post-burn itch may improve the early identification and treatment of burn patients developing chronic itch.
Itch (pruritus) is a common multidimensional complaint after burn that can persist for months to years. A questionnaire able to investigate itch and its consequences is imperative for clinical and research purposes. The current study investigated the factor structure, internal consistency and construct validity of the Burns Itch Questionnaire (BIQ), a questionnaire particularly focusing on itch in the burns population. The BIQ was completed by 195 respondents at 3 months after burn. An exploratory factor analysis (EFA) was performed to investigate the factor structure. EFA showed the BIQ comprised three latent factors: itch severity, sleep interference and daily life interference. This was re-evaluated in a confirmatory factor analysis that yielded good fit indices after removing two items. The three subscales showed to have high internal consistency (.89) and were able to distinguish between patients with severe and less severe complaints. In conclusion, the BIQ showed to be useful in persons suffering from itch following burns.
OBJECTIVE: To evaluate the effect of doxepin hydrochloride 5% cream on reducing pruritus in burn scar patients compared to a placebo cream.METHOD: We conducted a multicenter triple-blind randomized clinical placebo-controlled crossover trial in which burn patients ≥18 years with an itch intensity ≥3 on a Visual Analogue Scale (VAS) were randomized between a doxepin-placebo or placebo-doxepin treatment protocol. Patients used each cream during two weeks with a wash-out period of one week in between. Primary outcome was change in itch intensity in two weeks' time using the VAS. Secondary outcome included the impact of itch (Burn Itch Questionnaire). Other parameters were the use of hydrating cream, silicon treatment, pressure garments, and other antipruritic medication.RESULTS: Twenty-seven patients were included. The change in itch intensity (VAS) was not different during the doxepin and placebo period (p=0.994); neither the doxepin cream nor placebo cream reduced itch intensity. However, based on the Burn Itch Questionnaire, we observed a statistically significant decrease in itch intensity and improvement in impact scores in both treatment groups, but no difference in the degree of reduction between the groups.CONCLUSION: Doxepin cream was not effective in reducing pruritus in our burn patient study population.
Developing and testing several AR and VR concepts for SAMSUNG (Benelux) Samsung and Breda University of Applied Sciences decided to work together on developing and testing several new digital media concepts with a focus on VR and gaming. This collaboration has led to several innovative projects and concepts, among others: the organisation of the first Samsung VR jam in which game and media students developed new concepts for SAMSUNG GEAR in 24 hours, the pre-development of a VR therapy concept (Fear of Love) created by CaptainVR, the Samsung Industry Case in which students developed new concepts for SAMSUNG GEAR (wearables), the IGAD VR game pitch where over 15 VR game concepts were created for SAMSUNG VR GEAR and numerous projects in which VR concepts are developed and created using new SAMSUNG technologies. Currently we are co-developing new digital HRM solutions.
In de land- en tuinbouwsector worden UAV’s gebruikt om op basis van sensorwaarnemingen telers adviezen te geven om de teelt te optimaliseren. De buitenteelt is verder in de ontwikkeling en het gebruik van UAV’s dan de binnenteelt. In de buitenteelt kunnen drones autonoom vliegen via een vooraf ingestelde route m.b.v. GPS-waypoint. Het is niet mogelijk om deze GPS-techniek toe te passen in de bedekte teelten i.v.m. onvoldoende GPS-signaal in de kassen. Daarnaast wordt er in de kas hinder ondervonden van verschillende obstakels, zoals gewasdraden, gewaswagens en personeel. Kortom er zijn grote verschillen tussen binnen- en buitenteelt op dit gebied. De uitdaging is om een UAV autonoom te laten navigeren in de binnenteelt. Het idee achter dit project is om een vooronderzoek uit te voeren naar de mogelijkheden om drones autonoom te laten navigeren in de glastuinbouw. Indien dit mogelijk is kunnen hyperspectrale camera’s die momenteel worden gebruikt in de open teelten ook toegepast worden in de binnenteelt. De Twirre architectuur biedt een goed uitgangspunt om het autonoom vliegen met drones in een kas te ontwikkelen. De projectpartners hebben met dit KIEM project de volgende doelstellingen: • Inventariseren welke sensoren gebruikt kunnen worden om in een kas de positie van een drone te bepalen, • Inventariseren welke sensoren gebruikt kunnen worden om in een kas obstakels te kunnen detecteren die ontweken moeten worden • keuzes maken voor positie- en antibots-sensoren, deze integreren in de Twirre architectuur, • een drone met de uitgebreide Twirre architectuur testen in een kas, de positie nauwkeurigheid te meten en de botspreventie te testen, • de beelden van de camera worden op basis van positie informatie en standhoekinformatie van de camera aan elkaar gestitcht tot een grote foto die de hele kas beslaat, • daarmee de basis leggen voor een vervolgproject gericht op het ontwikkelen van een beslissingsondersteunend platform dat op basis van sensorwaarnemingen de teler adviezen geeft om zijn teelt te optimaliseren.
The research for alternatives to substitute cement in concrete increased in the last years to reduce the environmental impact. Geopolymers or alkali-activated materials are one of the options. The proposed project aims to obtain a wet cell based on a geopolymer with alginate and natural fibres. The wet cell will be a final prototype composed of panels for wet construction areas such as bathrooms and kitchens. There is a lack of biobased solutions for wet areas currently in the market. And the present project, together with companies of suppliers and users from the market, aims to provide a solution for a wet cell using biobased materials. The natural fibres added to the geopolymer will substitute a portion of sand and gravel, producing a lighter product than concrete. Also, the fibres increase the thermal and acoustic insulation. Natural fibres should be pretreated to increase the bond with other materials in the mixture. The chemical used in the alkali-activated materials is the same to pretreat the fibres. Also, alginates extracted from seaweeds can be used as binders, and alkali is used in the extraction process. One of the objectives is to develop the method and technique to produce geopolymer with alginates and pretreat the fibre simultaneously during the mixture. After defining the optimum mixture for the geopolymer, panels will be produced, and in the end, a wet cell will be constructed with the geopolymer panels.
![The World of the [open] innovator](https://publinova-harvester-content-acc.s3.amazonaws.com/thumbnails/files/previews/pdf/20240409032959354250.042ed686-762c-429d-ba80-1c82380cb051-thumbnail-400x300.png)
