Background: Hypothyroidism is a common endocrine disorder and the standard treatment is replacement therapy with levothyroxine (LT4). Although many hypothyroid patients improve upon treatment with LT4, a proportion seems to experience residual hypothyroid complaints despite treatment, even when plasma TSH and FT4 are within reference ranges. Methods: Using an on-line survey we investigated 1. the health-related quality of life (QoL) (ThyPRO), 2. the activities of daily living (SF-36), 3. hypothyroid-related symptoms (ThySHI) in diagnosed, treated hypothyroid patients (>18 years, treated >6 months) and control persons (without thyroid disease, >18 years). In patients, the time course of symptoms from diagnosis until 3 years was asked (retrospectively, ThySHI). Patients and control persons were recruited by e-mails from patient organizations, posters in pharmacies and health centers and Twitter/Facebook. For data analysis (ThyPRO, 0-100 scale, t-test; daily functioning, 1-5 scale and ThySHI 0-3 scale, Mann-Whitney; time course symptoms, Friedmann-Dunnett; confounding factors, ANCOVA) IBM SPSS 24 was used. Results: In this cohort consisted of 1667 patients (mean duration of illness 12.2 ± SD 9.9 years) and 275 controls. Treated hypothyroid patients had 1. a significant decrease in health-related QoL and all domains (fatigue, vitality, cognition, anxiety, depressivity, emotional susceptibility, social life, daily life), as compared to controls (mean total QoL 39.9 vs 19.1 resp. and all domains p<0.001), 2. Significantly more impairment with activities of daily living (p<0.001), and 3. significantly higher scores for symptoms related to hypothyroidism, as compared to control persons (all p<0.01). Symptoms generally decreased after 3 years of treatment, with fatigue, reduce daily functioning, coldness, muscle pain/cramps and being overweight as the most intense residual complaints. Many patients (78.5%) reported having complaints despite taking thyroid medication and reported not feeling well (77.8%) while their blood values were within range. TSH level, age, gender and duration of illness did not significantly affect total QoL, whereas the M3 comorbidity index did. Desiccated thyroid hormone users (9.4%) had a significantly better mean total QoL than LT4 users (90.5%) (36,0 vs 40.6, p=0.003). Conclusions: Persistent complaints, such as reduced health-related quality of life, reduced daily functioning, and residual hypothyroid related symptoms, are common in this group of hypothyroid patients despite replacement therapy. Caregivers should be aware that persistent complaints can be present in treated hypothyroid patients, despite following current guidelines, and that these remaining symptoms may affect their quality of life and daily functioning.
Purpose: The aim of this study was to investigate the effect of possible late effects of cancer treatment (physical complaints, fatigue, and cognitive complaints) and of two job resources (autonomy and supportive leadership style) on future burnout complaints, among employees living 2–10 years beyond breast cancer diagnosis.Methods: Data at T1 (baseline questionnaire) and at T2 (9 months later) were collected in 2018 and 2019 (N = 287). These data were part of a longitudinal study among Dutch speaking workers with a cancer diagnosis 2–10 years ago. All complaints and job resources were self-reported. Longitudinal multivariate regression analyses were executed, controlling for years since diagnosis, living with cancer (recurrence or metastasis), and other chronic or severe diseases. Mediation by baseline burnout complaints was considered.Results: A higher level of fatigue and cognitive complaints at baseline (T1) resulted in higher future burnout complaints (at T2), with partial mediation by baseline burnout complaints. No effect of physical complaints at T1 was observed. Higher levels of autonomy or a supportive leadership style resulted in lower burnout complaints, with full mediation by baseline burnout complaints. Buffering was observed by autonomy in the relationship of cognitive complaints with future burnout complaints. No moderation was observed by supportive leadership.Conclusion: The level of burnout complaints among employees 2–10 years beyond breast cancer diagnosis may be an effect of fatigue or cognitive complaints, and awareness of this effect is necessary. Interventions to stimulate supportive leadership and autonomy are advisable, the latter especially in the case of cognitive complaints.
Purpose: The aim of this study was to investigate the occupational well-being among employees with chronic diseases, and the buffering effect of four job resources, possibly offering targets to enhance occupational well-being.Method: This cross-sectional study (N = 1951) was carried out among employees in educational and (semi-)governmental organizations in the Netherlands. The dimensions of the survey were chronic diseases (i.e., physical, mental, or both physical and mental), occupational well-being (i.e., work ability, burnout complaints, and work engagement), and job resources (i.e., autonomy, social support by colleagues, supportive leadership style, and open and communicative culture). First, it was analyzed if chronic diseases were associated with occupational well-being. Second, it was analyzed if each of the four job resources would predict better occupational well-being. Third, possible moderation effects between the chronic disease groups and each job resource on occupational well-being were examined. Regression analyses were used, controlling for age.Results: Each chronic disease group was associated with a lower work ability. However, higher burnout complaints and a lower work engagement were only predicted by the group with mental chronic diseases and by the group with both physical and mental chronic disease(s). Furthermore, all four job resources predicted lower burnout complaints and higher work engagement, while higher work ability was only predicted by autonomy and a supportive leadership style. Some moderation effects were observed. Autonomy buffered the negative relationship between the chronic disease groups with mental conditions (with or without physical conditions) and work ability, and the positive relationship between the group with both physical and mental chronic disease(s) and burnout complaints. Furthermore, a supportive leadership style is of less benefit for occupational well-being among the employees with mental chronic diseases (with or without physical chronic diseases) compared to the group employees without chronic diseases. No buffering was demonstrated for social support of colleagues and an open and communicative organizational culture.Conclusion: Autonomy offers opportunities to reinforce occupational well-being among employees with mental chronic diseases. A supportive leadership style needs more investigation to clarify why this job resource is less beneficial for employees with mental chronic diseases than for the employees without chronic diseases.
Individuals are increasingly confronted with ‘diseases of modernity’, such as stress and burnout. While insights from the work-family interface have mainly pointed towards demands and resources coming from the work and nonwork domains, the proposed multi-method PhD research project aims to contribute to contemporary scholarly and societal work-life and burnout debates by presenting an alternative theoretical lens on the development of mental health complaints in today’s society, especially among the younger Millennial generation. The project aims to shed light on how and why Millennial employees engage in a so-called ‘work/nonwork image (re)construction process’.The project will reflect on the following questions:How, why and when do individual workers engage in a process in which they construct their image(s) in the work and nonwork domains? What are the relationships, if any, between the image (re)construction process individuals engage in and potential positive- and negative consequences?The findings are expected to have important implications not only for preventive measures for individuals and organizations, but also for possible avenues for future studies. Project Partner: Nyenrode Business Universiteit
De zorgbehoeftes van patiënten met nek- en/of schouderklachten kunnen per persoon verschillen. We onderzoeken of de fysiotherapie verbeterd kan worden door dit te personaliseren en met een online programma te combineren.Doel Het doel van dit project is het verbeteren van de fysiotherapeutische zorg voor patiënten met nek- en/of schouderklachten. Door de vorm en inhoud aan te passen aan de behoeftes van de individuele patiënt denken we de therapie (kosten-)effectiever te maken. We willen dat zoveel mogelijk fysiotherapeuten deze behandeling kunnen toepassen. Daarnaast gebruiken we de kennis uit dit onderzoek in het opleiden van professionals in de gezondheidszorg. Resultaten Dit onderzoek loopt nog. Na afronding vind je hier een samenvatting van de resultaten. Looptijd 01 juni 2018 - 01 juni 2023 Aanpak We bieden de fysiotherapeut hulpmiddelen om te bepalen of een patiënt geschikt is voor blended fysiotherapie en om te bepalen hoe de behandeling er dan uit zou moeten zien. Blended fysiotherapie is een integratie van consulten fysiotherapie en een digitaal programma waarmee patiënten thuis aan de slag gaan, zoals het bestaande E- Excercise. Deze zogenoemde gestratificeerde blended fysiotherapie behandeling vergelijken we met gebruikelijke fysiotherapie op (kosten-)effectiviteit. Lees hier het wetenschappelijk artikel dat Mark van Tilburg en collega-onderzoekers erover publiceerden: Stratified care integrated with eHealth versus usual primary care physiotherapy in patients with neck and/or shoulder complaints: protocol for a cluster randomized controlled trial
De zorgbehoeftes van patiënten met nek- en/of schouderklachten kunnen per persoon verschillen. We onderzoeken of de fysiotherapie verbeterd kan worden door dit te personaliseren en met een online programma te combineren.Doel Het doel van dit project is het verbeteren van de fysiotherapeutische zorg voor patiënten met nek- en/of schouderklachten. Door de vorm en inhoud aan te passen aan de behoeftes van de individuele patiënt denken we de therapie (kosten-)effectiever te maken. We willen dat zoveel mogelijk fysiotherapeuten deze behandeling kunnen toepassen. Daarnaast gebruiken we de kennis uit dit onderzoek in het opleiden van professionals in de gezondheidszorg. Resultaten Dit onderzoek loopt nog. Na afronding vind je hier een samenvatting van de resultaten. Looptijd 01 juni 2018 - 01 juni 2023 Aanpak We bieden de fysiotherapeut hulpmiddelen om te bepalen of een patiënt geschikt is voor blended fysiotherapie en om te bepalen hoe de behandeling er dan uit zou moeten zien. Blended fysiotherapie is een integratie van consulten fysiotherapie en een digitaal programma waarmee patiënten thuis aan de slag gaan, zoals het bestaande E- Excercise. Deze zogenoemde gestratificeerde blended fysiotherapie behandeling vergelijken we met gebruikelijke fysiotherapie op (kosten-)effectiviteit. Lees hier het wetenschappelijk artikel dat Mark van Tilburg en collega-onderzoekers erover publiceerden: Stratified care integrated with eHealth versus usual primary care physiotherapy in patients with neck and/or shoulder complaints: protocol for a cluster randomized controlled trial
