Hedonic (happiness) and eudaimonic (meaning in life) well-being are negatively related to depressive symptoms. Genetic variants play a role in this association, reflected in substantial genetic correlations. We investigated the overlap and differences between well-being and depressive symptoms, using results of Genome-Wide Association studies (GWAS) in UK Biobank. Subtracting GWAS summary statistics of depressive symptoms from those of happiness and meaning in life, we obtained GWASs of respectively “pure” happiness (neffective = 216,497) and “pure” meaning (neffective = 102,300). For both, we identified one genome-wide significant SNP (rs1078141 and rs79520962, respectively). After subtraction, SNP heritability reduced from 6.3% to 3.3% for pure happiness and from 6.2% to 4.2% for pure meaning. The genetic correlation between the well-being measures reduced from 0.78 to 0.65. Pure happiness and pure meaning became genetically unrelated to traits strongly associated with depressive symptoms, including loneliness, and psychiatric disorders. For other traits, including ADHD, educational attainment, and smoking, the genetic correlations of well-being versus pure well-being changed substantially. GWAS-by-subtraction allowed us to investigate the genetic variance of well-being unrelated to depressive symptoms. Genetic correlations with different traits led to new insights about this unique part of well-being. Our results can be used as a starting point to test causal relationships with other variables, and design future well-being interventions.
MULTIFILE
How well-being changes over the course of a vacation is unclear. Particular understudied areas include the eudaimonic dimension of well-being, the comparison between eudaimonia and hedonia, and the role of activity type. Using an integrated model, two studies which combined survey and experiment were conducted to examine the change patterns of eudaimonia and hedonia, the difference of change patterns between eudaimonia and hedonia, and the moderating role of activity type. Hedonia and eudaimonia both significantly changed via a ‘first rise then fall’ change tendency over the course of a vacation. Compared to hedonia, eudaimonia has lower change intensity over the course of a vacation; eudaimonia achieved in a challenging (vs. relaxing) activity is more. Theoretical and managerial implications are discussed.
MULTIFILE
There has been a rapidly growing number of studies of the geographical aspects of happiness and well-being. Many of these studies have been highlighting the role of space and place and of individual and spatial contextual determinants of happiness. However, most of the studies to date do not explicitly consider spatial clustering and possible spatial spillover effects of happiness and well-being. The few studies that do consider spatial clustering and spillovers conduct the analysis at a relatively coarse geographical scale of country or region. This article analyses such effects at a much smaller geographical unit: community areas. These are small area level geographies at the intra-urban level. In particular, the article presents a spatial econometric approach to the analysis of life satisfaction data aggregated to 1,215 communities in Canada and examines spatial clustering and spatial spillovers. Communities are suitable given that they form a small geographical reference point for households. We find that communities’ life satisfaction is spatially clustered while regression results show that it is associated to the life satisfaction of neighbouring communities as well as to the latter's average household income and unemployment rate. We consider the role of shared cultural traits and institutions that may explain such spillovers of life satisfaction. The findings highlight the importance of neighbouring characteristics when discussing policies to improve the well-being of a (small area) place.
