As society has to adapt to changing energy sources and consumption, it is driving away from fossil energy. One particular area of interest is electrical driving and the increasing demand for (public) charging facilities. For municipalities, it is essential to adapt to this changing demand and provide more public charging facilities.In order to accommodate on roll-out strategies in metropolitan areas a data driven simulation model, SEVA1, has been developed The SEVA base model used in this paper is an Agent-Based model that incorporate past sessions to predict future charging behaviour. Most EV users are habitual users and tend to use a small subset of the available charge facilities, by that obtaining a pattern is within the range possibilities. Yet, for non-habitual users, for example, car sharing users, obtaining a pattern is much harder as the cars use a significantly higher amount of charge points.The focus of this research is to explore different model implementations to assess the potential of predicting free-floating cars from the non-habitual user population. Most important result is that we now can simulate effects of deployement of car sharing users in the system, and with that the effect on convenience for habitual users. Results show that the interaction between habitual and non habitual EV users affect the unsuccessful connection attempts based increased based on the size of the car-sharing fleet up to approximately 10 percent. From these results implications for policy makers could be drawn.
MULTIFILE
As society has to adapt to changing energy sources and consumption, it is driving away from fossil energy. One particular area of interest is electrical driving and the increasing demand for (public) charging facilities. For municipalities, it is essential to adapt to this changing demand and provide more public charging facilities.In order to accommodate on roll-out strategies in metropolitan areas a data driven simulation model, SEVA1, has been developed The SEVA base model used in this paper is an Agent-Based model that incorporate past sessions to predict future charging behaviour. Most EV users are habitual users and tend to use a small subset of the available charge facilities, by that obtaining a pattern is within the range possibilities. Yet, for non-habitual users, for example, car sharing users, obtaining a pattern is much harder as the cars use a significantly higher amount of charge points.The focus of this research is to explore different model implementations to assess the potential of predicting free-floating cars from the non-habitual user population. Most important result is that we now can simulate effects of deployement of car sharing users in the system, and with that the effect on convenience for habitual users. Results show that the interaction between habitual and non habitual EV users affect the unsuccessful connection attempts based increased based on the size of the car-sharing fleet up to approximately 10 percent. From these results implications for policy makers could be drawn.
MULTIFILE
Huntington’s disease (HD) and various spinocerebellar ataxias (SCA) are autosomal dominantly inherited neurodegenerative disorders caused by a CAG repeat expansion in the disease-related gene1. The impact of HD and SCA on families and individuals is enormous and far reaching, as patients typically display first symptoms during midlife. HD is characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia. SCAs are mainly characterized by ataxia but also other symptoms including cognitive deficits, similarly affecting quality of life and leading to disability. These problems worsen as the disease progresses and affected individuals are no longer able to work, drive, or care for themselves. It places an enormous burden on their family and caregivers, and patients will require intensive nursing home care when disease progresses, and lifespan is reduced. Although the clinical and pathological phenotypes are distinct for each CAG repeat expansion disorder, it is thought that similar molecular mechanisms underlie the effect of expanded CAG repeats in different genes. The predicted Age of Onset (AO) for both HD, SCA1 and SCA3 (and 5 other CAG-repeat diseases) is based on the polyQ expansion, but the CAG/polyQ determines the AO only for 50% (see figure below). A large variety on AO is observed, especially for the most common range between 40 and 50 repeats11,12. Large differences in onset, especially in the range 40-50 CAGs not only imply that current individual predictions for AO are imprecise (affecting important life decisions that patients need to make and also hampering assessment of potential onset-delaying intervention) but also do offer optimism that (patient-related) factors exist that can delay the onset of disease.To address both items, we need to generate a better model, based on patient-derived cells that generates parameters that not only mirror the CAG-repeat length dependency of these diseases, but that also better predicts inter-patient variations in disease susceptibility and effectiveness of interventions. Hereto, we will use a staggered project design as explained in 5.1, in which we first will determine which cellular and molecular determinants (referred to as landscapes) in isogenic iPSC models are associated with increased CAG repeat lengths using deep-learning algorithms (DLA) (WP1). Hereto, we will use a well characterized control cell line in which we modify the CAG repeat length in the endogenous ataxin-1, Ataxin-3 and Huntingtin gene from wildtype Q repeats to intermediate to adult onset and juvenile polyQ repeats. We will next expand the model with cells from the 3 (SCA1, SCA3, and HD) existing and new cohorts of early-onset, adult-onset and late-onset/intermediate repeat patients for which, besides accurate AO information, also clinical parameters (MRI scans, liquor markers etc) will be (made) available. This will be used for validation and to fine-tune the molecular landscapes (again using DLA) towards the best prediction of individual patient related clinical markers and AO (WP3). The same models and (most relevant) landscapes will also be used for evaluations of novel mutant protein lowering strategies as will emerge from WP4.This overall development process of landscape prediction is an iterative process that involves (a) data processing (WP5) (b) unsupervised data exploration and dimensionality reduction to find patterns in data and create “labels” for similarity and (c) development of data supervised Deep Learning (DL) models for landscape prediction based on the labels from previous step. Each iteration starts with data that is generated and deployed according to FAIR principles, and the developed deep learning system will be instrumental to connect these WPs. Insights in algorithm sensitivity from the predictive models will form the basis for discussion with field experts on the distinction and phenotypic consequences. While full development of accurate diagnostics might go beyond the timespan of the 5 year project, ideally our final landscapes can be used for new genetic counselling: when somebody is positive for the gene, can we use his/her cells, feed it into the generated cell-based model and better predict the AO and severity? While this will answer questions from clinicians and patient communities, it will also generate new ones, which is why we will study the ethical implications of such improved diagnostics in advance (WP6).
The consistent demand for improving products working in a real-time environment is increasing, given the rise in system complexity and urge to constantly optimize the system. One such problem faced by the component supplier is to ensure their product viability under various conditions. Suppliers are at times dependent on the client’s hardware to perform full system level testing and verify own product behaviour under real circumstances. This slows down the development cycle due to dependency on client’s hardware, complexity and safety risks involved with real hardware. Moreover, in the expanding market serving multiple clients with different requirements can be challenging. This is also one of the challenges faced by HyMove, who are the manufacturer of Hydrogen fuel cells module (https://www.hymove.nl/). To match this expectation, it starts with understanding the component behaviour. Hardware in the loop (HIL) is a technique used in development and testing of the real-time systems across various engineering domain. It is a virtual simulation testing method, where a virtual simulation environment, that mimics real-world scenarios, around the physical hardware component is created, allowing for a detailed evaluation of the system’s behaviour. These methods play a vital role in assessing the functionality, robustness and reliability of systems before their deployment. Testing in a controlled environment helps understand system’s behaviour, identify potential issues, reduce risk, refine controls and accelerate the development cycle. The goal is to incorporate the fuel cell system in HIL environment to understand it’s potential in various real-time scenarios for hybrid drivelines and suggest secondary power source sizing, to consolidate appropriate hybridization ratio, along with optimizing the driveline controls. As this is a concept with wider application, this proposal is seen as the starting point for more follow-up research. To this end, a student project is already carried out on steering column as HIL
Possibly, the aviation sector’s decarbonization challenge (see Dutch knowledge key in international climate study for tourism | CELTH) has profound implications for the ability of aviation-de-pendent outbound tour operators to attract capital and with that their ability to maintain or trans-form their current business portfolio (understood here as the current product offers and approximate carbon footprints, business models, and ownership structures present in this economic do-main). Knowledge about these (possible) investment risks and their business and policy implications is lacking. This project therefore addresses this knowledge gap by means of the following research questions.1. What is the current business portfolio of Dutch outbound tour operators?a. To what extend do Dutch outbound tour operators depend on aviation in terms of product offer and turnover?b. What is the relative carbon footprint share of aviation-based products compared to the total outbound product offer and turnover of Dutch outbound tour operators?2. What are investment risks of this business portfolio as indicated by investors?a. How do investors evaluate investment risks in relation to climate change mitigation and de-carbonisation?b. What are investment risks of the business portfolio of Dutch outbound tour operators?c. What are the reflections on and implications of these investment risks from the perspective of policymakers and tour operators?
