Zoekresultaten

Natural language processing in toxicology: Delineating adverse outcome pathways and guiding the application of new approach methodologies

Adverse Outcome Pathways (AOPs) are conceptual frameworks that tie an initial perturbation (molecular initiat- ing event) to a phenotypic toxicological manifestation (adverse outcome), through a series of steps (key events). They provide therefore a standardized way to map and organize toxicological mechanistic information. As such, AOPs inform on key events underlying toxicity, thus supporting the development of New Approach Methodologies (NAMs), which aim to reduce the use of animal testing for toxicology purposes. However, the establishment of a novel AOP relies on the gathering of multiple streams of evidence and infor- mation, from available literature to knowledge databases. Often, this information is in the form of free text, also called unstructured text, which is not immediately digestible by a computer. This information is thus both tedious and increasingly time-consuming to process manually with the growing volume of data available. The advance- ment of machine learning provides alternative solutions to this challenge. To extract and organize information from relevant sources, it seems valuable to employ deep learning Natural Language Processing techniques. We review here some of the recent progress in the NLP field, and show how these techniques have already demonstrated value in the biomedical and toxicology areas. We also propose an approach to efficiently and reliably extract and combine relevant toxicological information from text. This data can be used to map underlying mechanisms that lead to toxicological effects and start building quantitative models, in particular AOPs, ultimately allowing animal-free human-based hazard and risk assessment.

New approach methodologies (NAMs) for human-relevant biokinetics predictions

For almost fifteen years, the availability and regulatory acceptance of new approach methodologies (NAMs) to assess the absorption, distribution, metabolism and excretion (ADME/biokinetics) in chemical risk evaluations are a bottleneck. To enhance the field, a team of 24 experts from science, industry, and regulatory bodies, including new generation toxicologists, met at the Lorentz Centre in Leiden, The Netherlands. A range of possibilities for the use of NAMs for biokinetics in risk evaluations were formulated (for example to define species differences and human variation or to perform quantitative in vitro-in vivo extrapolations). To increase the regulatory use and acceptance of NAMs for biokinetics for these ADME considerations within risk evaluations, the development of test guidelines (protocols) and of overarching guidance documents is considered a critical step. To this end, a need for an expert group on biokinetics within the Organisation of Economic Cooperation and Development (OECD) to supervise this process was formulated. The workshop discussions revealed that method development is still required, particularly to adequately capture transporter mediated processes as well as to obtain cell models that reflect the physiology and kinetic characteristics of relevant organs. Developments in the fields of stem cells, organoids and organ-on-a-chip models provide promising tools to meet these research needs in the future.

Higher education’s responsibility for balanced professionalism

Most higher education alumni work in professional fields, making higher education responsible for the provision of high-quality professionalism throughout society. However, higher education does not yet fulfil its role as a provider of methodologies for the renewal of professionalism. In this lecture, Didi Griffioen outlines the characteristics of professionalism, asserting that current methodologies for the continuous renewal of different elements of professionalism are lacking. By positioning itself as provider of these methodologies, higher education can play a more relevant role in society while also contributing to its own professional renewal and innovativeness.

Research results of a new combined method in climate adaptation

Cities are becoming increasingly vulnerable for climate change and there is an urgent needto become more resilient. This research involves the development of the City climate scanRotterdam (September 2017) methodology to measure, map, scan and assess differentparameters that together give insight in the vulnerability of urban areas and neighborhoods.The research at recent City climate scan / Sketch your city in April 2018 used storytelling andsketching1 as main method to connect stakeholders, motivate action, evoke recognition in ajointly formulated goal, such as taking climate action. The city climate scan also involved thedevelopment of a set of measurement tools that can be applied in different urbanneighborhoods in a low-cost low-tech approach with teams of stakeholders andpractitioners. The city climate scan method was tested in different cities around the globe(Rotterdam, Manila and Cebu) in groups of young professionals and stakeholders in rapidurban appraisals.

Research results of a new combined method in climate adaptation

High Resolution Decision Maps for Urban Planning: A Combined Analysis of Urban Flooding and Thermal Stress Potential In Asia and Europe

Urban flooding and thermal stress have become key issues for many cities around the world. With the continuing effects of climate change, these two issues will become more acute and will add to the serious problems already experienced in dense urban areas. Therefore, the sectors of public health and disaster management are in the need of tools that can assess the vulnerability to floods and thermal stress. The present paper deals with the combination of innovative tools to address this challenge. Three cities in different climatic regions with various urban contexts have been selected as the pilot areas to demonstrate these tools. These cities are Tainan (Taiwan), Ayutthaya (Thailand) and Groningen (Netherlands). For these cities, flood maps and heat stress maps were developed and used for the comparison analysis. The flood maps produced indicate vulnerable low-lying areas, whereas thermal stress maps indicate open, unshaded areas where high Physiological Equivalent Temperature (PET) values (thermal comfort) can be expected. The work to date indicates the potential of combining two different kinds of maps to identify and analyse the problem areas. These maps could be further improved and used by urban planners and other stakeholders to assess the resilience and well-being of cities. The work presented shows that the combined analysis of such maps also has a strong potential to be used for the analysis of other challenges in urban dense areas such as air and water pollution, immobility and noise disturbance.